Applying histatin 1 to improve integration of dental implants

Histatins are peptides exclusively present in the saliva of higher primates. They are secreted by the salivary glands and play an important role in protection of the mouth. Recently it was found that one of the histatins, histatin 1 (Hst1), improves cellsubstrate adhesion as well as cell-cell adhesion, suggesting a role in maintenance of the epithelial architecture and barrier function.

The effect of Hst1 on cell-substrate adhesion is very pronounced. In vitro studies show that even on glass, a substrate on which adherent cells not readily attach, cells attach rapidly in the presence of Hst1. Preliminary results also show that Hst1 improves cell adhesion on titanium.


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