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Classification of sepsis patients as 4 blood genomic endotypes with prognostic and pathophysiological implications

Sepsis remains a remarkable adversary to medicine, characterized by poor prognosis and high mortality rates. Despite the burden on patients, their families and the health care system, treatment remains mainly supportive. Unrecognized population substructures and the heterogeneity in the host response complicate the identification of high-risk patients who would benefit from specific adjuvant therapy. Blood transcriptional profiling has provided substantial advances in the context of sepsis. Although promising new diagnostic biomarkers have emerged from the application of blood genomics to sepsis, patient selection for interventional trials and prognostication in sepsis continue to be driven by clinical criteria.

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