Novel insight into drug action in the central nervous system using pharmacological MRI

While PET and SPECT techniques provide targeted imaging of specific molecules, the usage of radioisotopes limits extensive use in vulnerable human subjects (e.g. peadiatric population) and compared to MRI methods, spatial resolution is poor. A new non invasive imaging technique is pharmacological MRI
(phMRI). phMRI differs from functional (f)MRI in that the neuronal system is not activated by a motor or
cognitive task, but pharmacologically. phMRI has great potential for better understanding the effects of
neuropharmacological manipulations on the functional connectivity of brain structures.


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