A means of assessing abuse liability of experimental drugs in man using MRI methods and evaluating and mitigating abuse risk of novel Mechanisms-of-Action.
Assessment of abuse potential of experimental drugs that engage with novel Mechanisms of Action is required as part of their development. The FDA strongly encourages industry to pay more attention to the risk for drug abuse in experimental drugs to avoid future non-medical use.
Today, a variety of preclinical animal models for drug dependence and abuse exist albeit with varying translational properties. Because of this, innovative drug development faces a significant risk of choosing a suboptimal animal model, dosing and administration regime.
Click here to download the information sheet on this collaboration opportunity (PDF, 193kb)
For more information, please contact:
The Amsterdam imaging core that offers access to both conventional (3 Tesla) and ultra- high field (7 Tesla) MRI facilities for fundamental and clinical research into the workings of the brain and brain disorders. Click here to download the brochure (PDF, 131kb) For more information contact:
Drug target discovery in neuroscience is increasingly relying on human samples to generate meaningful data that translates into actionable strategies. Open access to well-characterized brain tissue of high quality is crucial to obtain these insights and is the goal of the Netherlands Brain Bank. Click here to download the information sheet on this collaboration opportunity […]
HepaRG cells outperform all other proliferative sources of human hepatocytes in liver functions. Now we modified the HepaRG cell line by stable lentiviral overexpression of the constitutive androstane receptor (CAR), a regulator of e.g. detoxification and energy metabolism, which has the following advantages: High liver functionality & increased mitochondrial energy metabolism in monolayer, particularly in […]