Funding for novel lysosomal protease inhibitors for the treatment of Alzheimer’s disease
January 24, 2024Alzheimer’s disease is becoming a healthcare burden of epidemic proportions for which there is no cure. UvA researcher Dr. Ewelina Weglarz-Tomczak addresses the underlying molecular mechanisms of neurodegeneration in the disease. She will be bringing her invention one step closer to clinic with a €100,000 proof-of-concept grant by IXA to evaluate the designed lead structures in cell-based models.
It is estimated that there are approximately 44 million people worldwide living with Alzheimer’s disease (AD) or a related form of dementia. AD has no cure, there are two recently approved antibody treatments that demonstrate removing β-amyloid (βA), one of the hallmarks of AD. Still, they are highly controversial due to their severe side effects such as brain swelling or bleeding (up to 40% of patients).
New treatment with novel lysosomal protease inhibitors
Dr. Ewelina Weglarz-Tomczak’s approach addresses the underlying biology of the disease by targeting two highly specified lysosomal protease (proteolytic enzyme located in lysosomes which
breaks down targeted proteins) which are the key factors in the molecular mechanisms of neurodegeneration in AD. AI-powered technology developed by NatInLab (spin-off company of Dr. Ewelina Weglarz-Tomczak’s) has led to the discovery of how that protease is controlled in the human organism. Based on this knowledge, developing novel, highly effective and safe inhibitors of targeted protease is possible.
Proof-of-concept grant
IXA has provided Dr. Ewelina Weglarz-Tomczak support in bringing her invention one step closer to clinic with a €100,000 proof-of-concept grant to evaluate the designed lead structures in cell-based models. The project aims to deliver new agents against Alzheimer’s and possibly other neurodegenerative diseases as the next step.
More information
More news
Max Nieuwdorp’s innovative research on gut microbes: a path to combat fatty liver disease
Internist Max Nieuwdorp, of Amsterdam UMC, discovered a few years ago that the microorganisms in the intestines of many overweight people produce alcohol to an increased extent. Breaking down excessive alcohol leads to fatty liver disease, which in turn poses a risk of serious conditions such as diabetes and cardiovascular disease. Nieuwdorp has now received an ERC Advanced Grant of 2.5 million euros for a major study into the underlying causes of this excessive alcohol production.
News
Impact in education and beyond: VU researcher Laura Rupp secures Comenius Leadership Fellow grant
Laura Rupp has been awarded the Comenius Leadership Fellow grant for a three-year period. This grant of 500,000 Euros, will fund a project titled “Global English and International Dutch on the VU Campus”. Over the years, Rupp has successfully reached more than 100,000 people online worldwide, teaching how to understand diverse English accents and speak […]
News
Funding from KWF for palliative cancer patients in meaning-making at home
The diagnosis of incurable cancer profoundly disrupts patients’ lives, often causing existential crises and a sense of lost purpose. The KWF-funded project “In Search of Stories” (ISOS) aimed to support these patients by partnering them with spiritual counsellors and professional artists. This co-creation process proved highly beneficial. New funding from KWF Dutch Cancer Society supports […]
News